On encountering an eyelid or orbital mass, apart from common skin lesions, the diagnosis requires systemic evaluation, radiological and eventually histological confirmation. The majority are uncommon conditions for ophthalmologists.1 The presenting signs in all soft tissue NEOPLASMs and carcinomas are rather similar with lid swelling and proptosis. In this edition Langerhans cell histiocytosis (LCH), granular cell tumor (GCT) and eyelid conjunctival amyloidosis have been reported. In all the diagnosis is based on confirmation of an adnexal mass and by imaging followed by a histopathological report along with systemic investigation.

Background and Aim: Conventional cancer treatments usually have complex complications. Also, the resistance of cancer cells to treatments is a special point that indicates the need for alternative therapies such as the use of herbal compounds. The aim of this study was to evaluate the anticancer effect of aqueous extract of Persia rose on ORAL cancer cell line. Material and Methods: In this experimental study, the toxicity effect of aqueous extract of Persia rose with different concentrations over 48 hours and repeated 5 times on the viability of human ORAL carcinoma cells (NCBI cell line No # C152) and Normal gingival fibroblast cells (HF2FF cell line) were examined by MTT method and finally, the optical density of the solution obtained at 570 nm was read by Elisa Reader. The results were evaluated using Two Way ANOVA test and Tukey POST HOC test was used to compare concentrations. Results: The results showed that the aqueous extract of Persia rose had a negative effect on the viability of cancer cell line compared to the control group and reduced the viability of cancer cells. This effect was inversely related to increasing the extract concentration. However, this effect did not show a statistically significant difference (p> 0. 05). Decreased viability in normal gingival fibroblasts was also observed due to the use of different concentrations of the extract (p> 0. 05). Two-way ANOVA test showed that the interaction between the independent variable (extract concentration) and the dependent variable (cell viability) was not significant depending on the independent variable (cancer cell type or healthy) (p> 0. 8). Conclusion: It seems Persia rose extract cause reduction of cancer cells and normal gingival fibroblasts viability.

Background: Pancreatic simple cysts are smaller than the complex cysts and are located in distal areas of pancreas. Papillary solid and cystic tumor is a rare NEOPLASM in children and elderly, and often occurs in young women and girls.Case Report: A forty-year-old woman with a history of epigastria pain for five years had referred several times to medical centers was conducted to be candidate to pancreatic systectomy with general anesthesia. She underwent distal pancreatectomy. Patient postoperative follow-up was continued.Conclusion: Papillary solid and cystic tumor of the pancreas is a rare NEOPLASM with unknown origin and often benign. It presents with vague abdominal pain. Ultrasound, magnetic resonance imaging (MRI) and CT-scan would help to make diagnosis before the surgery. Surgery is the choice treatment and the diagnosis would be proved with histology and immunohistochemistry.

Ovarian sex cord-stromal tumors are relatively infrequent NEOPLASMs that account for approximately 8% of all primary ovarian NEOPLASM. Sex cord-stromal tumors of the ovary include granulosa cell tumors, fibrothecomas, Sertoli-Leydigcell tumors, steroid cell tumors, and sclerosing stromal tumors (SST). Sclerosing stromal tumors account for 2% to 6% of ovarian stromal tumors. Despite the rarity of this particular NEOPLASM, it is not always possible to predict the presence of this tumor preoperatively on the basis of clinical and sonographic findings. Histopathological and immunohistochemical (IHC) examinations confirm the diagnosis. Herein, the clinical findings and histopathological features of SST are described in a 24-year-old female.

Background and Aim: ORAL mucosal lesions have various prevalence rates among different populations. Few studies have evaluated the frequency of ORAL mucosal lesions in Iranian population. This study aimed to determine the frequency of ORAL mucosal lesions and the related factors. Methods and Materials: This descriptive study was conducted based on the data in the archives of two referral centers, including the Pathology Departments of the Cancer Institute of Imam Khomeini and Buali hospitals in Tehran, from June 2000 to July 2014. Age, sex, location of the lesions and microscopic diagnosis were retrieved from the files, and the data were analyzed by SPSS13 using Chi-square test. Results: Among 59273 files, 976 patients (1. 56%) had ORAL mucosal lesions, and the most prevalent pathologies were epithelial lesions (89. 4%), followed by connective tissue lesions (6. 5%). Squamous Cell Carcinoma (53%) was the most prevalent epithelial lesion. The most common location of ORAL mucosal lesions was the lips (27. 8%). Mean age of the patients was 44 ± 3 years. The incidence of mucosal lesions increased with age, while no correlation was observed between mucosal lesions and sex (P<0. 9). Conclusion: The most prevalent ORAL mucosal lesion was the Squamous Cell Carcinoma, which is a malignant tumor with epithelial origin, and its early diagnosis is necessary.

Background: Perivascular Epithelioid Cell Tumors (PEComas) are rare mesenchymal tumors originating from perivascular epithelioid cells. The second common affected organ is uterine. Most of PEComas are benign and patients have good prognosis. At the present time, surgery is the main treatment and adjuvant chemotherapy is used in malignant cases, although the best diagnostic and management method is yet to be discovered considering the rarity of this NEOPLASM. Case Presentation: The patient was a 53 year old lady with a history of two vaginal deliveries and no previous surgery. She had severe pelvic pain and underwent MRI with the primary impression of sarcoma. In MRI, she had a 7 cm mass in lower segment of uterus. The patient underwent laparoscopic hysterectomy, bilateral oophorectomy, lymphadenectomy, and omental biopsy in Jam Hospital. Pathologic report of the patient revealed malignant PEComa without lymph node and omentum involvement. Conclusion: Diagnosis of PEComa before surgery is difficult and its differential diagnoses form uterine leiomyoma or leiomyosarcoma. Final diagnosis can be made after surgical biopsy and immunohistochemistry evaluation. Surgery is still the main treatment and adjuvant therapy is used in high risk patients.

Tumors of the central nervous system (CNS), occur relatively frequently during the early years of life. They are the most common solid tumors of childhood and are second only to leukemia in overall cancer incidence and account for a high proportion of deaths. In different studied performed in several countries, astrocytomas and other gilomas (combined) account for half of the CNS malignancies, followed by PNET/MB, and ependymomas, and then craniopharyngioma. We have undertaken a perspective study with 349 brain tumor patients, ranging from 0-14 years of age, throughout a five- year period (1998-2003). Who were admitted in Tabriz children hospital or were diagnosed in Tabriz Hafez imaging center, during radiological evaluation by CT. Craniopharyngioma was the most common type of tumors among patients studied in our Series, and astrocytomas was second and medulloblastoma was third common type. The Male/Female proportion of patients in total brain tumors according to our results is 1.56 and it is similar to previous studies. About medulloblastoma and ependymomas, Male/Female proportion of patients in this study is less than 1 (0.88, 0.7), but in previous series it seems to be more than 1 (about 1.4). Age- related distribution of brain tumors in children under the age 14 was similar to that of other series to some extent. Also, since the causes and risk factors of CNS cancers remain largely undetermined, we could not reach a significant relationship between the tumors and residency of patients. Hope our results make a useful for the future studies in this field, and differences obtained in this study with results of other series, can help us more and more in management and treatment strategies in brain tumors in children of our population.

Lipoma is one of the most common benign NEOPLASMs with predominant occurrence in lower organs and is rarely reported in ORAL cavity. Pathogenesis lipoma is unclear but has a higher incidence among fat people. Metabolism of lipoma is independent of fat of body and comes as a yellow submucous mass with no signs and intact surface. In this case, 57 years woman who used complete denture was referred to ORAL medicine clinic of Ahwaz faculty of dentistry. After evaluation ORAL cavity and clinical examination, yellow exophytic mass with soft consistency and 1.5 to 2 cm in size was seen in right retromolar as pedunculated mass. After taking her medical history, it was found out that this mass had developed in her ORAL cavity 3 years previously and pathology report confirmed lipoma.

Sarcomatoid squamous cell carcinomas are extremely rare, high grade, aggressive variant of penile cancers. Sarcomatoid carcinoma are biphasic NEOPLASMs with a combination of both sarcomatoid components and carcinomatous elements. These NEOPLASMs are very rare in the urogenital system. We report a 53-year-old male presented with an ulcerated lesion on the glans penis. The rarity of this case reiterates the importance of thorough morphological and histological examination along with immunohistochemistry in diagnosing, staging, treatment and follow up of patients.